The term cell-free synthetic biology describes the non-fermentative production of high value molecules based on multi-enzyme cascades, to be used e.g. for the food and pharmaceutical industries. According to such definition, it does not require living microorganisms and therefore is a powerful platform to produce even hardly accessible and complex compounds with extremely high space-time-yields. c-LEcta as a leading company in this field has already brought several processes to market maturity and is steadily improving its technology.
The key enabling step is based on c-LEcta’s core competence, namely to develop enzymes with highest activity and outstanding stability so that they can perfectly cope with industrial conditions while having the lowest cost contribution. Especially co-factor dependent and energy consuming reactions require sophisticated alignment and are therefore a target of the new collaboration project together with Prof. Thomas Walther from the Technical University of Dresden. The collaboration is funded by the Federal Ministery for Economic Affairs and Energy under the central innovation program for SME (“Zentrales Innovationsprogramm Mittelstand” or “ZIM”).
Through the cooperation of c-LEcta with Prof. Thomas Walther from the Institute of Bioprocess Engineering, innovative approaches and economic process development are ideally combined. As Prof. Thomas Walther says: “Finding cost-efficient ways of providing chemical energy to cell free systems will greatly expand their field of application. I am glad I have found c-LEcta as an industrial partner to work on this ambitious idea.” Dr. Andreas Vogel, Head of R&D, Enzyme Development from c-LEcta adds “The collaboration with Thomas is a perfect match to overcome the limitations of living cell systems and enable new synthetic enzymatic routes to compounds that cannot be economically produced so far.”